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Krusemark Research Lab

PUBLICATIONS

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  • Wang, S., Denton, K. D., Hobbs, K. F., Weaver, T., McFarland, J. M. B., Connelly, K. E., Gignac, M. C., Milosevich, N., Hof, F., Paci, I., Musselman, C. A., Dykhuizen, E. C., Krusemark, C. J., “Optimization of Ligands using Focused DNA-encoded Libraries to Develop a Selective, Cell-permeable CBX8 Chromodomain Inhibitor.” ACS Chem. Biol. 2020, 15, 112-131. link
  • Cai, B., Kim, D., Akhand, S., Sun, Y., Cassell, R., Alpsoy, A., Dykhuizen, E. C., Van Rijn, R. M., Wendt, M. K., Krusemark, C. J., "Selection of DNA-encoded Libraries to Protein Targets Within and On Living Cells." J. Am. Chem. Soc. 2019, 141, 17057-17061. link
  • Kim, D., Sun, Y., Xie, D., Denton, K. E., Chen, H., Lin, H., Wendt, M. K., Post, C. B., Krusemark, C. J., "Application of a Substrate-Mediated Selection with c-Src Tyrosine Kinase to a DNA-encoded Chemical Library." Molecules. 2019, 24(15), 2764. link
  • Shinde, A., Hardy, S. D., Kim, D., Akhand, S. S., Jolly, M. K., Wang, W. H., Anderson, J. C., Khodadadi, R. B., Brown, W. S., George, J. T., Liu, S., Wan, J., Levine, H., Willey, C. D., Krusemark, C. J., Geahlen, R. L., Wendt, M. K., "Spleen Tyrosine Kinase-Mediated Autophagy is Required for Epithelial-Mesenchymal Plasticity and Metastasis in Breast Cancer." Cancer Research. 2019, 79(8), 1831-1843. link
  • Denton, K. E., Wang, S., Gignac, M. C., Milosevich, N., Hof, F., Dykhuizen, E. C., Krusemark, C. J., "Robustness of In Vitro Selection Assays of DNA-Encoded Peptidomimetic Ligands to CBX7 and CBX8." SLAS Discovery. 2018, 23, 417-418. link
  • Kim, D., Jetson, R. R., Krusemark, C. J., "A DNA-assisted immunoassay for enzyme activity via a DNA-linked, activity-based probe." ChemComm. 2017, 53, 9474-9477. link
  • Denton, K. E., Krusemark, C. J., "Crosslinking of DNA-linked ligands to target proteins for enrichment from DNA-encoded libraries." MedChemComm. 2016, 7, 2020-2027. link
  • Jetson, R. R., Krusemark, C. J., "Sensing Enzymatic Activity by Exposure and Selection of DNA-encoded Probes." Angewandte Chemie Int. Ed. 2016, 55, 9562-9566. link
  • Krusemark, C. J., Tilmans, N. P., Brown, P. O., Harbury, P. B., "Directed Chemical Evolution with an Outsized Genetic Code." PloS ONE. 2016, 11(8) e0154765. doi:10.1371/journal.pone.0154765. link​
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